Interuniversity Consortium, CINECA, is the largest data centre in Italy, one of the most important on a global level. It supports the scientific community via Supercomputing and its applications, produces management systems for university administrators and for the Ministry of University and Research, designs and develops IT systems for Public Administration, health and businesses.

European Centre for Medium-Range Weather Forecasts  is an intergovernmental organisation with headquarters in Reading, UK, and offices in Bologna, Italy, and Bonn, Germany. It operates using one of the most powerful Supercomputers in the world, to implement meteorology research activities and services mainly dedicated to its State Members and global users. The Centre hosts one of the world's largest meteorological data archives.

The National Research Centre in High Performance Computing, Big Data and Quantum Computing, established  and managed by the ICSC Foundation, is one of the five National Centres established by the National Recovery and Resilience Plan (PNRR). It carries out research and development activities  both nationally and internationally  with the aim of fostering innovation in the field of simulations, high-performance computing and data analysis.

CNAF is the main computing center of INFN (National Institute of Nuclear Physics). It is responsible for the management and development of the main computational and data management services supporting INFN. Since 2003, CNAF has hosted the Italian Tier-1 for the High Energy Physics experiments at the Large Hadron Collider in Geneva, providing resources, support and the necessary services for data storage, distribution, and data analysis activities.